Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model.

ABSTRACT: Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a major health concern that often leads to long-lasting complications. However, the electrophysiological events that occur immediately after traumatic brain injury, and may underlie impact outcomes, have not been fully elucidated. To investigate the electrophysiological events that immediately follow traumatic brain injury, a weight-drop model of traumatic brain injury was used in rats pre-implanted with epidural and intracerebral electrodes. Electrophysiological (near-direct current) recordings and simultaneous alternating current recordings of brain activity were started within seconds following impact. Cortical spreading depolarization (SD) and SD-induced spreading depression occurred in approximatel

SUBMITTER: Aboghazleh R 

PROVIDER: S-EPMC8584184 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature