The effect of systemic administration of salicylate on the auditory cortex of guinea pigs.

ABSTRACT:

Objective

To investigate the effect of systemic administration of salicylate as a tinnitus inducing drug in the auditory cortex of guinea pigs.

Methods

Extracellular recording of spikes of the primary auditory cortex and dorsocaudal areas in healthy male albino Hartley guinea pigs was continuously performed (pre- and post-salicylate).

Results

We recorded 160 single units in the primary auditory cortex from five guinea pigs and 156 single units in the dorsocaudal area from another five guinea pigs. The threshold was significantly elevated after the administration of salicylate in both the primary auditory cortex and dorsocaudal areas. The Q10dB value was significantly increased in the primary auditory cortex, whereas it has significantly decreased in the dorsocaudal ar

SUBMITTER: Kenmochi M 

PROVIDER: S-EPMC8584678 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature