Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells.

ABSTRACT: SELENOF is a member of the class of selenoproteins in which the amino acid selenocysteine is co-translationally inserted into the elongating peptide in response to an in-frame UGA codon located in the 3'-untranslated (3'-UTR) region of the SELENOF mRNA. Polymorphisms in the 3'-UTR are associated with an increased risk of dying from prostate cancer and these variations are functional and 10 times more frequent in the genomes of African American men. SELENOF is dramatically reduced in prostate cancer compared to benign adjacent regions. Using a prostate cancer tissue microarray, it was previously established that the reduction of SELENOF in the cancers from African American men was significantly greater than in cancers from Caucasian men. When SELENOF levels in human prostate immortalized ep

SUBMITTER: Hong LK 

PROVIDER: S-EPMC8584825 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature