Functional Selectivity of Dopamine D1 Receptor Signaling: Retrospect and Prospect.

ABSTRACT: Research progress on dopamine D1 receptors indicates that signaling no longer is limited to G protein-dependent cyclic adenosine monophosphate phosphorylation but also includes G protein-independent β-arrestin-related mitogen-activated protein kinase activation, regulation of ion channels, phospholipase C activation, and possibly more. This review summarizes recent studies revealing the complexity of D1 signaling and its clinical implications, and suggests functional selectivity as a promising strategy for drug discovery to magnify the merit of D1 signaling. Functional selectivity/biased receptor signaling has become a major research front because of its potential to improve therapeutics through precise targeting. Retrospective pharmacological review indicated that many D1 ligands have som

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8584964 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature