Blood Differential Gene Expression in Patients with Chronic Heart Failure and Systemic Iron Deficiency: Pathways Involved in Pathophysiology and Impact on Clinical Outcomes.

ABSTRACT:

Background

Iron deficiency is a common disorder in patients with heart failure and is related with adverse outcomes and poor quality of life. Previous experimental studies have shown biological connections between iron homeostasis, mitochondrial metabolism, and myocardial function. However, the mechanisms involved in this crosstalk are yet to be unfolded.

Methods

The present research attempts to investigate the intrinsic biological mechanisms between heart failure and iron deficiency and to identify potential prognostic biomarkers by determining the gene expression pattern in the blood of heart failure patients, using whole transcriptome and targeted TaqMan^® low-density array analyses.

Results

We performed a stepwise cross-sectional longitudinal study in a

SUBMITTER: Diez-Lopez C 

PROVIDER: S-EPMC8585093 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature