Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis.

ABSTRACT: The non-enzymatic addition of glucose (glycation) to circulatory and tissue proteins is a ubiquitous pathophysiological consequence of hyperglycemia in diabetes. Given the high incidence of periodontitis and diabetes and the emerging link between these conditions, it is of crucial importance to define the basic virulence mechanisms employed by periodontopathogens such as Porphyromonas gingivalis in mediating the disease process. The aim of this study was to determine whether glycated proteins are more easily utilized by P. gingivalis to stimulate growth and promote the pathogenic potential of this bacterium. We analyzed the properties of three commonly encountered proteins in the periodontal environment that are known to become glycated and that may serve as either protein su

SUBMITTER: Smiga M 

PROVIDER: S-EPMC8585099 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature