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Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia.


ABSTRACT: Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19 vaccines: Pfizer/BioNTech, AstraZeneca, Sputnik V, and Sinopharm. Functional antibody testing with a panel of nine SARS-CoV-2 viral variant receptor binding domain (RBD) proteins revealed marked differences in vaccine responses, with low antibody levels and RBD-ACE2 blocking activity stimulated by the Sinopharm and Sputnik V vaccines in comparison to the AstraZeneca or Pfizer/BioNTech vaccines. The Alpha variant caused 97% of infections in Mongolia in June and early July 2021. Individuals who recover from SARS-CoV-2 infection after vaccination achieve high antibody titers in most cases. These data suggest that public health interventions such as vaccine boosting, potentially with more potent vaccine types, may be needed to control COVID-19 in Mongolia and worldwide.

SUBMITTER: Dashdorj NJ 

PROVIDER: S-EPMC8585611 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia.

Dashdorj Naranjargal J NJ   Wirz Oliver F OF   Röltgen Katharina K   Haraguchi Emily E   Buzzanco Anthony S AS   Sibai Mamdouh M   Wang Hannah H   Miller Jacob A JA   Solis Daniel D   Sahoo Malaya K MK   Arunachalam Prabhu S PS   Lee Alexandra S AS   Shah Mihir M MM   Liu James J   Byambabaatar Sumiya S   Bat-Ulzii Purevjargal P   Enkhbat Anir A   Batbold Enkhtuul E   Zulkhuu Delgersaikhan D   Ochirsum Byambasuren B   Khurelsukh Tungalag T   Dalantai Ganbold G   Burged Natsagdorj N   Baatarsuren Uurtsaikh U   Ariungerel Nomin N   Oidovsambuu Odgerel O   Bungert Andreas S AS   Genden Zulkhuu Z   Yagaanbuyant Dahgwahdorj D   Mordorj Altankhuu A   Pulendran Bali B   Chinthrajah Sharon S   Nadeau Kari C KC   Jardetzky Theodore T   Wilbur James L JL   Wohlstadter Jacob N JN   Sigal George B GB   Pinsky Benjamin A BA   Boyd Scott D SD   Dashdorj Naranbaatar D ND  

Cell host & microbe 20211112 12


Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19 vaccines: Pfizer/BioNTech, AstraZeneca, Sputnik V, and Sinopharm. Functional antibody testing with a panel of nine SARS-CoV-2 viral variant receptor binding domain (RBD) proteins revealed marked differences in vaccine responses,  ...[more]

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