Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis.

ABSTRACT:

Background

Blood pressure lowering is an established strategy for preventing microvascular and macrovascular complications of diabetes, but its role in the prevention of diabetes itself is unclear. We aimed to examine this question using individual participant data from major randomised controlled trials.

Methods

We performed a one-stage individual participant data meta-analysis, in which data were pooled to investigate the effect of blood pressure lowering per se on the risk of new-onset type 2 diabetes. An individual participant data network meta-analysis was used to investigate the differential effects of five major classes of antihypertensive drugs on the risk of new-onset type 2 diabetes. Overall, data from 22 studies conducted between 1973 and 2008, were obtained by th

SUBMITTER: Nazarzadeh M 

PROVIDER: S-EPMC8585669 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature