Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy.

ABSTRACT: Built on neurodegenerative lesions models, the disrupted motor grounding hypothesis (DMGH) posits that motor-system alterations selectively impair action comprehension. However, major doubts remain concerning the dissociability, neural signatures, and etiological generalizability of such deficits. Few studies have compared action-concept outcomes between disorders affecting and sparing motor circuitry, and none has examined their multimodal network predictors via data-driven approaches. Here, we first assessed action- and object-concept processing in patients with frontal lobe epilepsy (FLE), patients with posterior cortex epilepsy (PCE), and healthy controls. Then, we examined structural and functional network signatures via diffusion tensor imaging and resting-state connectivity measures

SUBMITTER: Moguilner S 

PROVIDER: S-EPMC8585706 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature