Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice.

ABSTRACT: Acute and chronic liver disease are associated with substantial alterations in the hemostatic system, including elevated levels of the platelet-adhesive protein von Willebrand factor (VWF). Carbon tetrachloride-induced liver fibrosis is reduced in VWF-deficient mice, but it is unclear if VWF plays a pathologic role in all settings of liver fibrosis. Indeed, several studies suggest an anti-fibrotic role for components of the hemostatic system, including platelets, in experimental settings of bile duct fibrosis. However, the role of VWF in this specific pathology has not been examined. We tested the hypothesis that VWF exerts hepatoprotective effects in experimental bile duct injury. Wild-type and VWF-deficient (VWF^-/-) mice were challenged with the bile duct toxicant alpha-naphth

SUBMITTER: Poole LG 

PROVIDER: S-EPMC8585719 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature