Ubiquitination-Related Molecular Subtypes and a Novel Prognostic Index for Bladder Cancer Patients.

ABSTRACT: Objective: To develop and validate ubiquitination-related molecular subtypes and a novel prognostic index using ubiquitination-related genes (URGs) for patients with bladder cancer (BCa). Materials and Methods: We downloaded the clinical data and transcriptome data of BCa from TCGA and GEO database. Consensus clustering analysis was conducted to identify ubiquitination-related molecular subtypes for BCa. Besides, we performed univariate and multivariate Cox regression analysis to develop a novel prognostic URGs-related index for BCa. We conducted internal and external verification in TCGA cohort and GEO cohort, respectively. Furthermore, the associations of ubiquitination-related molecular subtypes and prognostic index with tumor immune environment were also investigated.

SUBMITTER: Cai H 

PROVIDER: S-EPMC8585742 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature