Different Drugs for the Treatment of Painful Diabetic Peripheral Neuropathy: A Meta-Analysis.

ABSTRACT: Objective: To systematically evaluate the effects of different drugs for the treatment of painful diabetic peripheral neuropathy. Methods: All literature from PubMed, Embase, and Cochrane Central Register of Controlled Trials published over the past 12 years (from January 1, 2008 to June 1, 2020) was searched, and two reviewers independently assessed study eligibility, continuous data extraction, independent assessment of bias risk, and graded strength of evidence. The pain score was used as the main result, and 30 and 50% pain reduction and adverse events were used as secondary results. Results: A total of 37 studies were included. Pregabalin, duloxetine, tapentadol, lacosamide, mirogabalin, and capsaicin were all more effective than placebo in alleviating the pain as

SUBMITTER: Jingxuan L 

PROVIDER: S-EPMC8585758 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature