Proteomic Phenotyping of Stimulated Muller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity.

ABSTRACT: Müller cells are the main macroglial cells of the retina exerting a wealth of functions to maintain retinal homoeostasis. Upon pathological changes in the retina, they become gliotic with both protective and detrimental consequences. Accumulating data also provide evidence for a pivotal role of Müller cells in the pathogenesis of diabetic retinopathy (DR). While microglial cells, the resident immune cells of the retina are considered as main players in inflammatory processes associated with DR, the implication of activated Müller cells in chronic retinal inflammation remains to be elucidated. In order to assess the signaling capacity of Müller cells and their role in retinal inflammation, we performed in-depth proteomic analysis of Müller cell proteomes and secretomes after stimulation wit

SUBMITTER: Schmalen A 

PROVIDER: S-EPMC8585775 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature