Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering.

ABSTRACT: The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue engineering. Peptides that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors, represent a unique group of bioactive agents for chondrogenic functionalization. Since they can be chemically synthesized, peptides bear better reproducibility, more stable efficacy, higher modifiability and yielding efficiency in comparison with natura

SUBMITTER: Zhu M 

PROVIDER: S-EPMC8585793 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature