Oligodendrocyte Lineage Marker Expression in eGFP-GFAP Transgenic Mice.

ABSTRACT: Oligodendrocytes, the myelinating cells of the central nervous system, orchestrate several key cellular functions in the brain and spinal cord, including axon insulation, energy transfer to neurons, and, eventually, modulation of immune responses. There is growing interest for obtaining reliable markers that can specifically label oligodendroglia and their progeny. In many studies, anti-CC1 antibodies, presumably recognizing the protein adenomatous polyposis coli (APC), are used to label mature, myelinating oligodendrocytes. However, it has been discussed whether anti-CC1 antibodies could recognize as well, under pathological conditions, other cell populations, particularly astrocytes. In this study, we used transgenic mice in which astrocytes are labeled by the enhanced green fluorescent

SUBMITTER: Behrangi N 

PROVIDER: S-EPMC8585802 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature