Updates in Prostate Cancer Research and Screening in Men at Genetically Higher Risk.

ABSTRACT:

Purpose of review

Prostate cancer (PrCa) is the most common cancer in men in the western world and is a major source of morbidity and mortality. Currently, general population PrCa screening is not recommended due to the limitations of the prostate-specific antigen (PSA) test. As such, there is increasing interest in identifying and screening higher-risk groups. The only established risk factors for PrCa are age, ethnicity, and having a family history of PrCa. A significant proportion of PrCa cases are caused by genetic factors.

Recent findings

Several rare germline variants have been identified that moderately increase risk of PrCa, and targeting screening to these men is proving useful at detecting clinically significant disease. The use of a "polygenic risk score" (PRS) th

SUBMITTER: Bancroft EK 

PROVIDER: S-EPMC8585808 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature