Post-acquisition CO₂ Inhalation Enhances Fear Memory and Depends on ASIC1A.

ABSTRACT: A growing body of evidence suggests that memories of fearful events may be altered after initial acquisition or learning. Although much of this work has been done in rodents using Pavlovian fear conditioning, it may have important implications for fear memories in humans such as in post-traumatic stress disorder (PTSD). A recent study suggested that cued fear memories, made labile by memory retrieval, were made additionally labile and thus more vulnerable to subsequent modification when mice inhaled 10% carbon dioxide (CO₂) during retrieval. In light of this finding, we hypothesized that 10% CO₂ inhalation soon after fear acquisition might affect memory recall 24 h later. We found that both cue and context fear memory were increased by CO₂ exposure after fe

SUBMITTER: Taugher RJ 

PROVIDER: S-EPMC8585996 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature