Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery.

ABSTRACT:

Objectives

The objective of this study was to identify novel serum biomarkers specific to postoperative delirium after major cardiac surgery to provide insight into the pathologic processes involved in delirium and its sequelae.

Design

Nested, case-control study.

Setting

Cardiac surgical intensive care unit in a single-site hospital setting.

Participants

The study comprised 24 older adults (aged >60 years) undergoing major cardiac surgery with cardiopulmonary bypass.

Interventions

None.

Measurements and main results

The primary outcome was a positive screen for delirium from postoperative days one through three based on criteria included in the long form of the Confusion Assessment Method. A multiplexed proteomic approach was applied using proximi

SUBMITTER: McKay TB 

PROVIDER: S-EPMC8586054 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature