The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries.

ABSTRACT: Wall shear stress (WSS), the frictional force of the blood on the vessel wall, plays a crucial role in atherosclerotic plaque development. Low WSS has been associated with plaque growth, however previous research used different approaches to define low WSS to investigate its effect on plaque progression. In this study, we used four methodologies to allocate low, mid and high WSS in one dataset of human coronary arteries and investigated the predictive power of low WSS for plaque progression. Coronary reconstructions were based on multimodality imaging, using intravascular ultrasound and CT-imaging. Vessel-specific flow was measured using Doppler wire and computational fluid dynamics was performed to calculate WSS. The absolute WSS range varied greatly between the coronary arteries. On the

SUBMITTER: Hartman EMJ 

PROVIDER: S-EPMC8586146 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature