Association between proton-pump inhibitors and the risk of gastric cancer: a systematic review with meta-analysis.

ABSTRACT:

Introduction

The use of proton-pump inhibitors (PPI) may be associated with an increased risk of gastric cancer (GC).

Objective

To review and meta-analyse available literature investigating the association between PPI use and GC risk.

Methods

Two independent reviewers systematically searched Ovid MEDLINE, EMBASE, and Cochrane Library (inception to July 2020) for case-control and cohort studies assessing the association between PPI use and GC according to a predefined protocol in PROSPERO (CRD42018102536). Reviewers independently assessed study quality, extracted data, and meta-analysed available and newly calculated odds ratios (ORs) using a random-effects model, and stratified for GC site (cardia versus non-cardia) and PPI duration (<1 year, 1-3 years, >3 year

SUBMITTER: Segna D 

PROVIDER: S-EPMC8586163 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature