Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34⁺ cells and causes decreased levels of hemoglobin.

ABSTRACT: Arsenic exposure poses numerous threats to human health. Our previous work in mice has shown that arsenic causes anemia by inhibiting erythropoiesis. However, the impacts of arsenic exposure on human erythropoiesis remain largely unclear. We report here that low-dose arsenic exposure inhibits the erythroid differentiation of human hematopoietic progenitor cells (HPCs). The impacts of arsenic (in the form of arsenite; As³⁺) on red blood cell (RBC) development was evaluated using a long-term culture of normal human bone marrow CD34⁺-HPCs stimulated in vitro to undergo erythropoiesis. Over the time course studied, we analyzed the expression of the cell surface antigens CD34, CD71 and CD235a, which are markers commonly used to monitor the progression of HPCs through the s

SUBMITTER: Wan G 

PROVIDER: S-EPMC8586241 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature