Ontology highlight
ABSTRACT:
SUBMITTER: Lenoir WF
PROVIDER: S-EPMC8586352 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Lenoir W Frank WF Morgado Micaela M DeWeirdt Peter C PC McLaughlin Megan M Griffith Audrey L AL Sangree Annabel K AK Feeley Marissa N MN Esmaeili Anvar Nazanin N Kim Eiru E Bertolet Lori L LL Colic Medina M Dede Merve M Doench John G JG Hart Traver T
Nature communications 20211111 1
CRISPR knockout fitness screens in cancer cell lines reveal many genes whose loss of function causes cell death or loss of fitness or, more rarely, the opposite phenotype of faster proliferation. Here we demonstrate a systematic approach to identify these proliferation suppressors, which are highly enriched for tumor suppressor genes, and define a network of 145 such genes in 22 modules. One module contains several elements of the glycerolipid biosynthesis pathway and operates exclusively in a s ...[more]