Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms.

ABSTRACT: The roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice in which all three NOS isoforms were deleted. Under basal conditions, the triple n/i/eNOSs^-/- mice displayed significantly longer mean alveolar linear intercept length, increased alveolar destructive index, reduced lung elastic fiber content, lower lung field computed tomographic value, and greater end-expiratory lung volume as compared with wild-type (WT) mice. None of single NOS^-/- or double NOSs^-/- genotypes showed such features. These findings were observed in the triple n/i/eNOSs^-/- mice as early as 4 weeks after birth. Cyclopaedic and quantitative comparisons of mRNA expression levels

SUBMITTER: Kato K 

PROVIDER: S-EPMC8586362 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature