Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy.

ABSTRACT: Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are complex co-occurring neurodevelopmental conditions. Their genetic architectures reveal striking similarities but also differences, including strong, discordant polygenic associations with educational attainment (EA). To study genetic mechanisms that present as ASD-related positive and ADHD-related negative genetic correlations with EA, we carry out multivariable regression analyses using genome-wide summary statistics (N = 10,610-766,345). Our results show that EA-related genetic variation is shared across ASD and ADHD architectures, involving identical marker alleles. However, the polygenic association profile with EA, across shared marker alleles, is discordant for ASD versus ADHD risk, indicating inde

SUBMITTER: Verhoef E 

PROVIDER: S-EPMC8586371 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature