Sex-Specific Pharmacotherapy for Back Pain: A Proof-of-Concept Randomized Trial.

ABSTRACT:

Background

Preventing transition to chronic back pain (CBP) is a long-sought strategy that could rescue patients from prolonged suffering. Recent rodent and human brain imaging studies suggest involvement of sexually dimorphic, dopaminergic-motivational, mesolimbic circuits in the transition to chronic pain (tCBP), and hint that the combination of carbidopa/levodopa and naproxen (LDP + NPX) may block tCBP. Here we evaluated, in people with recent-onset back pain, whether a 3-month treatment with LDP + NPX is safe, blocks tCBP, and whether its efficacy is sex-dependent.

Methods

A total of 72 participants were enrolled and stratified by risk for tCBP using brain-imaging biomarkers. Low-risk participants entered a no-treatment arm. Others were randomized to placebo + naproxen o

SUBMITTER: Reckziegel D 

PROVIDER: S-EPMC8586405 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature