RNA Biological Characteristics at the Peak of Cell Death in Different Hereditary Retinal Degeneration Mutants.

ABSTRACT: Purpose: The present work investigated changes in the gene expression, molecular mechanisms, and pathogenesis of inherited retinal degeneration (RD) in three different disease models, to identify predictive biomarkers for their varied phenotypes and to provide a better scientific basis for their diagnosis, treatment, and prevention. Methods: Differentially expressed genes (DEGs) between retinal tissue from RD mouse models obtained during the photoreceptor cell death peak period (Pde6b ^rd1 at post-natal (PN) day 13, Pde6b ^rd10 at PN23, Prph ^rd2 at PN29) and retinal tissue from C3H wild-type mice were identified using Illumina high-throughput RNA-sequencing. Co-expression gene modules were identified usi

SUBMITTER: Wei C 

PROVIDER: S-EPMC8586524 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature