Regulatory T Cells in Pregnancy Adverse Outcomes: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Several studies report the role of Regulatory T-cells (Tregs) in the pathophysiology of pregnancy adverse outcomes.

Objective

The aim of this systematic review and meta-analysis was to determine whether there is an association between regulatory T cell levels and pregnancy adverse outcomes (PAOs), including pre-eclampsia and preterm birth (PTB).

Method

Literature searches were conducted in PubMed/MEDLINE, Embase, and Cochrane CENTRAL databases. Inclusion criteria were original articles (clinical trials, case-control studies and cohort studies) comparing Tregs, sampled from the decidua or maternal blood, in healthy pregnant women versus women with pre-eclampsia or PTB. The outcome was standardised mean difference (SMD) in Treg numbers. The tau-squared

SUBMITTER: Green S 

PROVIDER: S-EPMC8586555 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature