Comprehensive Molecular and Cellular Characterization of Acute Kidney Injury Progression to Renal Fibrosis.

ABSTRACT: Acute kidney injury (AKI) and chronic kidney disease (CKD) represent different stages of renal failure; thus, CKD can be regarded as a result of AKI deterioration. Previous studies have demonstrated that immune cell infiltration, oxidative stress, and metabolic mentalism can support renal fibrosis progression in AKI cases. However, the most important triggers and cell types involved in this pathological progression remain unclear. This study was conducted to shed light into the underlying cellular and molecular features of renal fibrosis progression through the analysis of three mouse whole kidney and one human single-cell RNA-sequencing datasets publicly available. According to the different causes of AKI (ischemia reperfusion injury [IRI] or cisplatin), the mouse samples were divided int

SUBMITTER: Wu R 

PROVIDER: S-EPMC8586649 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature