Relationship between Fusobacterium nucleatum and antitumor immunity in colorectal cancer liver metastasis.

ABSTRACT: Fusobacterium nucleatum has been detected in 8%-13% of human colorectal cancer, and shown to inhibit immune responses against primary colorectal tumors in animal models. Thus, we hypothesized that the presence of F. nucleatum might be associated with reduced T cell density in colorectal cancer liver metastases (CRLM). We quantified F. nucleatum DNA in 181 CRLM specimens using quantitative PCR assay. The densities of CD8⁺ T cells, CD33⁺ cells (marker for myeloid-derived suppressor cells [MDSCs]), and CD163⁺ cells (marker for tumor-associated macrophages [TAMs]) in CRLM tissue were determined by immunohistochemical staining. Fusobacterium nucleatum was detected in eight (4.4%) of 181 CRLM specimens. Compared with F. nucleatum-negative CRLM, F. nucleatum-posit

SUBMITTER: Sakamoto Y 

PROVIDER: S-EPMC8586672 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature