PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma.

ABSTRACT: Ovarian clear cell carcinoma (CCC) exhibits an association with endometriosis, resistance to oxidative stress, and poor prognosis owing to its resistance to conventional platinum-based chemotherapy. A greater understanding of the molecular characteristics and pathogenesis of ovarian cancer subtypes may facilitate the development of targeted therapeutic strategies, although the mechanism of drug resistance in ovarian CCC has yet to be determined. In this study, we assessed exome sequencing data to identify new therapeutic targets of mitochondrial function in ovarian CCC because of the central role of mitochondria in redox homeostasis. Copy number analyses revealed that chromosome 17q21-24 (chr.17q21-24) amplification was associated with recurrence in ovarian CCC. Cell viability assays ident

SUBMITTER: Kitamura S 

PROVIDER: S-EPMC8586679 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature