Chemokine C-C motif ligand 21 synergized with programmed death-ligand 1 blockade restrains tumor growth.

ABSTRACT: Programmed death-ligand 1 (PD-L1) blockade has revolutionized the prognosis of several cancers, but shows a weak effect on pancreatic cancer (PC) due to poor effective immune infiltration. Chemokine C-C motif ligand 21 (CCL21), a chemokine promoting T cell immunity by recruiting and colocalizing dendritic cells (DCs) and T cells, serves as a potential antitumor agent in many cancers. However, its antitumor response and mechanism combined with PD-L1 blockade in PC remain unclear. In our study, we found CCL21 played an important role in leukocyte chemotaxis, inflammatory response, and positive regulation of PI3K-AKT signaling in PC using Metascape and gene set enrichment analysis. The CCL21 level was verified to be positively correlated with infiltration of CD8⁺ T cells by the CIB

SUBMITTER: Chen Q 

PROVIDER: S-EPMC8586683 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature