Ferroptosis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma.

ABSTRACT: Osteosarcoma has been the most common malignant bone tumor in children and adolescents, while the 5-y survival of osteosarcoma patients gained no significant improvement over the past decades. This study aimed to explore the role of ferroptosis-related genes (FRGs) in the development and prognosis of osteosarcoma. The datasets of osteosarcoma patients including RNA sequencing data and clinical information were acquired from the TRGET and Gene Expression Omnibus (GEO) databases. The identification of molecular subgroups with different FRG expression patterns was achieved through nonnegative matrix factorization (NMF) clustering. The prognostic model was constructed using the least absolute shrinkage and selection operator (LASSO) algorithm and multivariate Cox regression analysis. The ESTIM

SUBMITTER: Lei T 

PROVIDER: S-EPMC8586685 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature