Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer.

ABSTRACT: Pancreatic cancer frequently involves cancer-associated thromboembolism, which is strongly associated with poor prognosis. Tissue factor, a blood coagulation factor largely produced in cancer patients as a component of extracellular vesicles, plays a key role in the incidence of cancer-associated thromboembolism in patients with pancreatic cancer. However, no prospective studies have been published on the relationship between tissue factor and cancer-associated thromboembolism or patient clinical characteristics, including recent chemotherapy regimens. Thus, we aimed to address this in a Japanese cohort of 197 patients and 41 healthy volunteers. Plasma tissue factor levels were measured by ELISAs preevaluated by tissue factor specificity. Multivariable analysis was used to identify indepen

SUBMITTER: Kobayashi S 

PROVIDER: S-EPMC8586686 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature