Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Although the association between hypothyroidism and idiopathic pulmonary fibrosis (IPF) is found in observational studies, it remains uncertain whether hypothyroidism causally influences IPF.

Methods

Two-sample Mendelian randomisation (MR) was conducted with hypothyroidism genome-wide association study (GWAS) data in the UK Biobank from 289,307 individuals (18,740 cases and 270,567 controls) and the largest GWAS summary statistics of IPF from 11,259 individuals (2,668 cases and 8,591 controls). Findings were verified using an independent validation dataset, as well as through different MR methods with different model assumptions. A multivariable MR based on Bayesian model averaging was further performed to evaluate whether hypothyroidism, even given several other

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8586742 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature