Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19.

ABSTRACT:

Purpose

To study the effect of interferon-α2 auto-antibodies (IFN-α2 Abs) on clinical and virological outcomes in critically ill COVID-19 patients and the risk of IFN-α2 Abs transfer during convalescent plasma treatment.

Methods

Sera from healthy controls, cases of COVID-19, and other respiratory illness were tested for IFN-α2 Abs by ELISA and a pseudo virus-based neutralization assay. The effects of disease severity, sex, and age on the risk of having neutralizing IFN-α2 Abs were determined. Longitudinal analyses were performed to determine association between IFN-α2 Abs and survival and viral load and whether serum IFN-α2 Abs appeared after convalescent plasma transfusion.

Results

IFN-α2 neutralizing sera were found only in COVID-19 patients, with proportions increa

SUBMITTER: Raadsen MP 

PROVIDER: S-EPMC8586830 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature