Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates.

ABSTRACT:

Background

The heterogeneity in symptomatology and phenotypic profile attributable to COVID-19 is widely unknown. The objective of this manuscript is to conduct a trans-ancestry genome wide association study (GWAS) meta-analysis of COVID-19 severity to improve the understanding of potentially causal targets for SARS-CoV-2.

Methods

This cross-sectional study recruited 646 participants in the UAE that were divided into two phenotypic groups based on the severity of COVID-19 phenotypes, hospitalized (n=482) and non-hospitalized (n=164) participants. Hospitalized participants were COVID-19 patients that developed acute respiratory distress syndrome (ARDS), pneumonia or progression to respiratory failure that required supplemental oxygen therapy or mechanical ventilation support

SUBMITTER: Mousa M 

PROVIDER: S-EPMC8587122 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature