Toward an Extended Definition of Major Depressive Disorder Symptomatology: Digital Assessment and Cross-validation Study.

ABSTRACT:

Background

Diagnosing major depressive disorder (MDD) is challenging, with diagnostic manuals failing to capture the wide range of clinical symptoms that are endorsed by individuals with this condition.

Objective

This study aims to provide evidence for an extended definition of MDD symptomatology.

Methods

Symptom data were collected via a digital assessment developed for a delta study. Random forest classification with nested cross-validation was used to distinguish between individuals with MDD and those with subthreshold symptomatology of the disorder using disorder-specific symptoms and transdiagnostic symptoms. The diagnostic performance of the Patient Health Questionnaire-9 was also examined.

Results

A depression-specific model demonstrated good predictive

SUBMITTER: Martin-Key NA 

PROVIDER: S-EPMC8587324 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature