Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71).

ABSTRACT: Enterovirus 71 (EV-A71) is one of the predominant etiological agents of hand, foot and mouth disease (HMFD), which can cause severe central nervous system infections in young children. There is no clinically approved vaccine or antiviral agent against HFMD. The SP40 peptide, derived from the VP1 capsid of EV-A71, was reported to be a promising antiviral peptide that targeted the host receptor(s) involved in viral attachment or entry. So far, the mechanism of action of SP40 peptide is unknown. In this study, interactions between ten reported cell receptors of EV-A71 and the antiviral SP40 peptide were evaluated through molecular docking simulations, followed by in vitro receptor blocking with specific antibodies. The preferable binding region of each receptor to SP40 was predicted by global

SUBMITTER: Masomian M 

PROVIDER: S-EPMC8587434 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature