Neoadjuvant therapy or upfront surgery in advanced endometrial cancer: a systematic review protocol.

ABSTRACT:

Introduction

There is no consensus on the optimal treatment strategy for people with advanced endometrial cancer. Neoadjuvant therapies such as chemotherapy and radiotherapy have been employed to try to reduce the morbidity of surgery, improve its feasibility and/or improve functional performance in people considered unfit for primary surgery. The objective of this review is to assess whether neoadjuvant chemotherapy or radiotherapy improves health outcomes in people with advanced endometrial cancer when compared with upfront surgery.

Methods and analysis

This review will consider both randomised and non-randomised studies that compare health outcomes associated with the neoadjuvant therapy and upfront surgery in advanced endometrial cancer. Potential studies for inclusion w

SUBMITTER: McCarthy A 

PROVIDER: S-EPMC8587507 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature