A plain language summary of how well the single-dose Janssen vaccine works and how safe it is.

ABSTRACT: This is a summary of a publication about the ENSEMBLE trial of the Janssen Ad26.COV2.S vaccine against COVID-19, which was published in the New England Journal of Medicine in April 2021. The ENSEMBLE study started in September 2020 and is still ongoing. The study compared the effectiveness of the vaccine to a placebo in 43,783 adults from Latin America, South Africa, and the United States. Of those, 19,630 got a single dose of the vaccine. Compared to the placebo, the vaccine prevented: 66.9% of moderate to severe-critical COVID-19 cases after 14 days66.1% of moderate to severe-critical COVID-19 cases after 28 days85.4% of severe COVID-19 cases after 28 days100% of people with severe COVID-19 from needing to go to hospital for treatment None of the vaccinated participants died from

SUBMITTER: Sadoff J 

PROVIDER: S-EPMC8587777 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature