Comparison of Surface Functionalization of PLGA Composite to Immobilize Extracellular Vesicles.

ABSTRACT: Endothelialization by materials provides a promising approach for the rapid re-endothelialization of a cardiovascular implantation. Although previous studies have focused on improving endothelialization through the immobilization of bioactive molecules onto the surface of biodegradable implants, comparative studies of effective surface modification have not yet been reported. Here, we conducted a comparative study on the surface modification of poly(lactide-co-glycolide) (PLGA)-based composites to graft mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) using three different materials, fibronectin (FN), polyethylenimine (PEI), and polydopamine (PDA), which have different bond strengths of ligand-receptor interaction, ionic bond, and covalent bond, respectively. Further in vitro

SUBMITTER: Woo J 

PROVIDER: S-EPMC8587822 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature