Ontology highlight
ABSTRACT:
SUBMITTER: Liu YM
PROVIDER: S-EPMC8588048 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Liu Yu-Ming YM Fan Jing-Jing JJ Wang Li-Ning LN
Molecules (Basel, Switzerland) 20211108 21
Two rare guanidine-type alkaloids, Buthutin A (<b>1</b>) and Buthutin B (<b>2</b>), along with two other compounds (<b>3</b>, <b>4</b>), were isolated from <i>Buthus martensii</i> Karsch, and determined using extensive spectroscopic data analysis and high resolution-mass spectrometry. Compound <b>1</b> showed the most potent inhibition on AChE and BChE with IC<sub>50</sub> values of 7.83 ± 0.06 and 47.44 ± 0.95 μM, respectively. Kinetic characterization of compound <b>1</b> confirmed a mixed-typ ...[more]