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Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens.

ABSTRACT: In this study, the essential oil (EO) from Laurelia sempervirens was analyzed by GC/MS and safrole (1) was identified as the major metabolite 1, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (4 to 12) were obtained by the process. EO and compounds 4-12 were subjected to biological assays on 24 strains of the genus Saprolegnia, specifically of the species 12 S. parasitica and 12 S. australis. EO showed a significant effect against Saprolegnia strains. Compound 6 presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 µg/mL, respectively. The results show that compound 6 exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens.

SUBMITTER: Madrid A 

PROVIDER: S-EPMC8588113 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Chemical Analysis and <i>In Vitro</i> Bioactivity of Essential Oil of <i>Laurelia sempervirens</i> and Safrole Derivatives against Oomycete Fish Pathogens.

Madrid Alejandro A   Morales Ana Lizeth AL   Saffirio Valentina V   Cuellar Mauricio A MA   Werner Enrique E   Said Bastián B   Godoy Patricio P   Caro Nelson N   Melo Mirna M   Montenegro Iván I  

Molecules (Basel, Switzerland) 20211029 21

In this study, the essential oil (EO) from <i>Laurelia sempervirens</i> was analyzed by GC/MS and safrole (<b>1</b>) was identified as the major metabolite <b>1</b>, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (<b>4</b> to <b>12</b>) were obtained by the process. EO and compounds <b>4</b>-<b>12</b> were subjected to biological assays on 24 strains of the genus <i>Saprolegnia</i>, specifically of the species 12 <i>S.</  ...[more]

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