ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.

ABSTRACT:

Background

Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic, predictive of response to chemotherapy, and correlate with distinct tumor microenvironments.

Results

To reconcile these findings, we profile 22 human IDH-mutant gliomas using scATAC-seq and scRNA-seq. We determine the cell-type-specific differences in transcription factor expression and associated regulatory grammars between IDH-mutant glioma subtypes. We find that while IDH-mutant gliomas do share a common distribution of cell types, there are significant differences in the expression and targeting of transcription factors that r

SUBMITTER: Babikir H 

PROVIDER: S-EPMC8588616 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature