Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis.

ABSTRACT:

Background

Regulatory bodies recommend that all patients at risk of anaphylaxis be prescribed 2 epinephrine autoinjectors, which they should carry at all times. This is in contrast to some guidelines. The proportion of anaphylaxis reactions that are treated with multiple doses of epinephrine has not been systematically evaluated.

Objective

Our aim was to undertake a systematic review and meta-analysis of published studies reporting epinephrine treatment for anaphylaxis in which data relating to the number of doses administered were available.

Methods

We searched the Medline, Embase, and Cochrane databases for relevant studies reporting at least 10 anaphylaxis events (due to food or venom) from 1946 until January 2020. Data were extracted in duplicate for the meta-anal

SUBMITTER: Patel N 

PROVIDER: S-EPMC8588837 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature