Efficacy of acetazolamide for the prophylaxis of acute mountain sickness: A systematic review, meta-analysis, and trial sequential analysis of randomized clinical trials.

ABSTRACT:

Background

Acute mountain sickness (AMS) is a benign and self-limiting syndrome, but can progress to life-threatening conditions if leave untreated. This study aimed to assess the efficacy of acetazolamide for the prophylaxis of AMS, and disclose factors that affect the treatment effect of acetazolamide.

Methods

Randomized controlled trials comparing the use of acetazolamide versus placebo for the prevention of AMS were included. The incidence of AMS was our primary endpoint. Meta-regression analysis was conducted to explore factors that associated with acetazolamide efficacy. Trial sequential analyses were conducted to estimate the statistical power of the available data.

Results

A total of 22 trials were included. Acetazolamide at 125, 250, and 375 mg/bid significan

SUBMITTER: Gao D 

PROVIDER: S-EPMC8588948 | biostudies-literature | 2021 Oct-Dec

REPOSITORIES: biostudies-literature