New therapies in the treatment of melanoma.

ABSTRACT:

Introduction

Therapies targeting immune checkpoints (CTLA-4) and the MAP kinase signaling pathway (RAS/RAF/MEK/ERK) have transformed the treatment of advanced melanoma in the past year. Agents aimed at other therapeutic targets of interest are being actively evaluated in the clinic.

Areas covered

Areas of active therapeutic interest in melanoma include immunotherapy, molecularly targeted therapy and chemotherapy; combinations of these modalities are now under systematic exploration.

Expert opinion

The evaluation of patients with melanoma now includes the molecular profiling of tumor mutations in the BRAF, as well as c-Kit, NRAS and other genes that have been discovered to be drivers of different subsets of the disease. The analysis of the host immunological response t

SUBMITTER: Davar D 

PROVIDER: S-EPMC8589006 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature