Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation.

ABSTRACT: Homeostatic perturbation caused by infection fosters two major defense strategies, resistance and tolerance, which promote the host's survival. Resistance relates to the ability of the host to restrict the pathogen load. Tolerance minimizes collateral tissue damage without directly affecting pathogen fitness. These concepts have been explored mechanistically in murine models of malaria but only superficially in human disease. Indeed, individuals infected with Plasmodium vivax may present with asymptomatic malaria, only mild symptoms, or be severely ill. We and others have reported a diverse repertoire of immunopathological events that potentially underly susceptibility to disease severity in vivax malaria. Nevertheless, the combined epidemiologic, clinical, parasitological, and immunologic

SUBMITTER: Vinhaes CL 

PROVIDER: S-EPMC8589215 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature