Association of Age With Contrast-Enhancing Lesions Across the Multiple Sclerosis Disease Spectrum.

ABSTRACT:

Background and objectives

To investigate the association of age and the presence of contrast-enhancing lesions (CELs) on cranial MRI scans in different disease courses of multiple sclerosis (MS), we describe the frequency of CELs as a function of age in 4 large randomized controlled trial (RCT) datasets.

Methods

Using original trial data from CombiRx (Combination Therapy in Patients With Relapsing-Remitting Multiple Sclerosis; clinicaltrials.gov identifier NCT00211887), a trial in relapsing-remitting MS; ASCEND (A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosis; clinicaltrials.gov identifier NCT01416181), a trial in secondary progressive MS; and the 2 primary progressive MS trials

SUBMITTER: Koch MW 

PROVIDER: S-EPMC8589289 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature