Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration.

ABSTRACT:

Objective

To determine whether the Alzheimer disease (AD) dementia conversion-related pattern (ADCRP) on [¹⁸F]FDG PET can serve as a valid predictor for the development of AD dementia, the individual expression of the ADCRP (subject score) and its prognostic value were examined in patients with mild cognitive impairment (MCI) and biologically defined AD.

Methods

A total of 269 patients with available [¹⁸F]FDG PET, [¹⁸F]AV-45 PET, phosphorylated and total tau in CSF, and neurofilament light chain in plasma were included. Following the AT(N) classification scheme, where AD is defined biologically by in vivo biomarkers of β-amyloid (Aβ) deposition ("A") and pathologic tau ("T"), patients were categorized to the A-T-, A+T-, A+T+ (AD), and A-T+ gr

SUBMITTER: Blazhenets G 

PROVIDER: S-EPMC8589294 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature